[C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
نویسندگان
چکیده
Correspondence to: Dr. M. R. Turner, PO Box 41 (ANC), Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK E-mail: [email protected] Department of Neurology, PO Box 41, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK, MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK, PET Group, Translational Medicine & Technologies, GlaxoSmithKline, Cambridge, UK, Department of Neurology, Guy’s, King’s & St. Thomas’s School of Medicine, Academic Neuroscience Centre, King’s College Hospital, Denmark Hill, London SE5 9RS, UK and Institute of Neurology, Queen Square, London WC1N 3BG, UK
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[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.
The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear that neuronal loss is not confined to the motor cortex, even in cases without dementia. A reliable method of assessing cortical involvement in vivo remains elusive. WAY100635 binds selectively to the 5-hydroxytryptamine (5-HT1A) receptor, which is expressed on pyramidal neurones present throughout the c...
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